Eczema drug restores hair growth in teen with alopecia
濕疹藥物恢復脫髮青少年的毛髮生長
?▌ 部分素材來源於《福克斯新聞》，世界播團隊翻譯
After 11 months of dupilumab treatment, significant pigmented hair has grown across the patient"s scalp. (JAMA Network)
經過11個月的dupilumab治療，患者的頭皮上長出了大量的有色發毛。（美國醫學會雜誌官網）
Bald people have been given fresh hope after an eczema drug restored hair growth in a teenage girl with long-standing alopecia.
一種濕疹藥物恢復了一名長期脫髮少女的頭髮生長，這給了禿頭人士新的希望。
Doctors told how their 13-year-old patient, who has alopecia totalis - a total lack of scalp hair - as well as eczema, experienced "significant" hair regrowth while being treated with dupilumab, a drug marketed under the brand name Dupixent.
醫生講述了患有全禿(完全缺乏頭皮毛髮)以及濕疹的13歲患者，在名為Dupixent牌子的藥物dupilumab的治療下，是如何經歷了「顯著」的毛髮再生。
The unexpected side-effect came from treatment with dupilumab, which is approved for the treatment of moderate to severe eczema, also called atopic dermatitis.
意想不到的副作用來自dupilumab的治療，它被批準用於治療中度至重度濕疹，也稱為特應性皮炎。
"We were quite surprised since this patient hadn"t grown scalp hair since the age of 2, and other treatments that can help with hair loss did not in her case," lead study author Dr. Maryanne Makredes Senna, of Massachusetts General Hospital, said. "As far as we know, this is the first report of hair regrowth with dupilumab in a patient with any degree of alopecia areata."
「我們非常驚訝，因為這個病人從2歲起就沒有長出頭皮毛髮，其他有助於脫髮的治療方法也沒有。」 麻省總醫院的主要研究作者瑪麗安妮·馬克雷德斯·塞納博士說。「據我們所知，這是第一份關於任何程度斑禿患者使用dupilumab再生毛髮的報告。"
In addition to longstanding alopecia, this girl had also experienced extensive, treatment-resistant eczema since the age of seven months.
除了長期脫髮之外，這個女孩從7個月大就經歷了廣泛的抗治療濕疹。
Treatment with prednisone and methotrexate, medications that can suppress the overactive immune system, led to limited improvement in her eczema but no hair regrowth and was therefore discontinued.
用潑尼松和甲氨蝶呤治療，這種藥物可以抑製過度活躍的免疫系統，導致她的濕疹改善有限，但沒有毛髮再生，因此停止了。
In July 2017, she began to be treated with weekly injections of dupilumab, which had recently received official approval.
2017年7月，她開始接受每周注射dupilumab的治療，該藥物最近獲得了官方批準。
Fine light hairs called vellus hairs appear on the scalp of a patient with alopecia totalis six weeks after she began dupilumab treatment for eczema (JAMA Network)
一名患有全禿症的患者在開始接受dupilumab治療濕疹六周後，她的頭皮上出現了一種被稱為毳毛的細小毛髮。（美國醫學會雜誌官網）
After six weeks of treatment, which led to significant improvement in eczema symptoms, she also noticed that fine light hairs called vellus hairs were appearing on her scalp.
經過6周的治療，濕疹癥狀明顯改善，她還注意到她的頭皮上出現了一種叫做毳毛的纖細的淺色毛髮。
After seven months of dupilumab treatment, the girl had grown a "significant" amount of the pigmented hair that typically grows on the scalp.
經過7個月的dupilumab治療，這個女孩已經長出了大量的通常生長在頭皮上的有色頭髮。
Because of a change in her insurance coverage, she had to discontinue dupilumab for a two-month period, during which she noticed shedding of the recently regrown hair.
由於保險範圍的變化，她不得不中斷dupilumab兩個月，期間她注意到最近重新長出來的頭髮脫落了。
But after she could resume treatment in April this year, the hair growth resumed and has continued.
但在今年4月恢復治療後，她的頭髮又長了起來，而且還在繼續生長。
Senna explained that dupilumab"s mechanism of targeting a key immune system pathway known to be overactive in eczema could explain its action against alopecia, since recent studies have suggested other elements of the same pathway may induce autoimmune hair loss.
Senna解釋說，dupilumab的作用機制可以解釋其對抗脫髮的作用，因為最近的研究表明，同一途徑的其他成分可能導致自身免疫脫髮。
"Right now, it"s hard to know whether dupilumab could induce hair growth in other alopecia patients, but I suspect it may be helpful in patients with extensive active eczema and active alopecia areata," Senna said. "We"ve submitted a proposal for a clinical trial using dupilumab in this patient population and hope to be able to investigate it further in the near future."
「目前，我們還不清楚dupilumab是否能誘導其他脫髮患者的毛髮生長，但我懷疑它可能對廣泛的濕疹和斑禿有幫助。」 塞納說。「我們已經提交了一份在這一人群中使用dupilumab進行臨床試驗的提案，希望能在不久的將來對其進行進一步的研究。」
The findings were published by JAMA Dermatology,
這項研究結果發表在《美國醫學會皮膚病學》雜誌上，
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