國立台灣海洋大學：岩藻多糖可抑製肺癌細胞的轉移

原標題：岩藻多糖通過抑製VEGF和MMP抑製肺癌細胞在小鼠體內轉移

①岩藻多糖是一種含硫酸基的多糖，廣泛存在於褐藻中，具有很好的抗癌功效，能引起肝癌、乳腺癌、結腸癌細胞的凋亡，但是岩藻多糖抑製癌細胞轉移的機理研究尚不明確；

②本文以Lewis肺癌小鼠為模型，研究了岩藻多糖對腫瘤癥狀、腫瘤發展及轉移的作用；

③岩藻多糖能夠改善小鼠腫瘤癥狀，包括體重降低、肺部結節等；

④岩藻多糖通過抑製血管內皮生長因子（VEGF）和金屬基質蛋白酶（MMP）的表達，從而抑製肺癌細胞在小鼠體內的轉移。

⑤結論：岩藻多糖可以作為抑製癌細胞轉移的潛在藥物。

關鍵詞：岩藻多糖；肺癌；轉移；fucoidan

延伸閱讀

Mar. Drugs 2015, 13, 1882-1900

Prophylactic Administration of Fucoidan Represses Cancer Metastasis by Inhibiting Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinases (MMPs) in Lewis Tumor-Bearing Mice

Abstract:

Fucoidan, a heparin-like sulfated polysaccharide, is rich in brown algae. It has a wide assortment of protective activities against cancer, for example, induction of hepatocellular carcinoma senescence, induction of human breast and colon carcinoma apoptosis, and impediment of lung cancer cells migration and invasion. However, the anti-metastatic mechanism that fucoidan exploits remains elusive. In this report, we explored the effects of fucoidan on cachectic symptoms, tumor development, lung carcinoma cell spreading and proliferation, as well as expression of metastasis-associated proteins in the Lewis lung carcinoma (LLC) cells-inoculated mice model. We discovered that administration of fucoidan has prophylactic effects on mitigation of cachectic body weight loss and improvement of lung masses in tumor-inoculated mice. These desired effects are attributed to inhibition of LLC spreading and proliferation in lung tissues. Fucoidan also down-regulates expression of matrix metalloproteinases (MMPs), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and vascular endothelial growth factor (VEGF). Moreover, the tumor-bearing mice supplemented with fucoidan indeed benefit from an ensemble of the chemo-phylacticity. The fact is that fucoidan significantly decreases viability, migration, invasion, and MMPs activities of LLC cells. In summary, fucoidan is suitable to act as a chemo-preventative agent for minimizing cachectic symptoms as well as inhibiting lung carcinoma metastasis through downregulating metastatic factors VEGF and MMPs.

First Authors:

Tse-Hung Huang, Yi-Han Chiu

Correspondence:

Kuang-Hung Hs, Chang-Jer Wu

All Authors:

Tse-Hung Huang, Yi-Han Chiu, Yi-Lin Chan, Ya-Huang Chiu, Hang Wang, Kuo-Chin Huang, Tsung-Lin Li, Kuang-Hung Hsu and Chang-Jer Wu

2015-04-03 Article